Flowable composition that hardens on delivery to a target tissue site beneath the skin

摘要

Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.

主权项

1. An implantable drug depot for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the implantable drug depot comprising (i) a deployable balloon having a chamber, wherein the chamber comprises a channel and a closure member that can close said channel; and (ii) a flowable composition comprising an effective amount of a therapeutic agent, the composition disposed in the chamber of the balloon, wherein the flowable composition has a pre dosed modulus of elasticity of about 1×104 to about 3×105 dynes/cm2 and is disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day, and the drug depot comprises a polymer comprising polyethylene glycol with pendant hydroxyl groups (PEGH).