| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a spirocyclic isoxazoline derivative of formulawhere each of Y and Z is C; each of W, Wand Wis C; A together with Y and Z is a 5-member heterocyclic ring, wherein said heterocyclic ring contains 1 heteroatom selected from N and O, and wherein the ring A is optionally substituted with at least one substitute selected from oxo and C-Calkyl; each of R, Rand Ris independently hydrogen, halogen or C-Chaloalkyl; Ris C-Chaloalkyl; Ris -C(O)R; Ris C-Calkyl, C-CalkylC-Ccycloalkyl, C-Calkylheteroaryl, where said heteroaryl is pyrazolyl, or C-Calkylheterocycle, where said heterocycle is thietanyl; each C-Calkyl or C-CalkylC-Ccycloalkyl group of Rcan be optionally and independently substituted with at least one substitute selected from halogen, hydroxyl, C-Chaloalkyl, C-Calkyl, hydroxylC-Calkyl- and -S(O)Rgroups; and each C-Calkylheteroaryl or C-Calkylheterocyclic group of Rcan optionally be further substituted with at least one substitute selected from oxo and C-Calkyl; Ris C-Calkyl or C-Chaloalkyl; n equals 0; p equals 0, 1 or 2; andis a single or double bond; stereoisomers thereof and veterinary-acceptable salts thereof. The invention also relates to spirocyclic isoxazoline derivatives of formulaand specific derivatives thereof. Spirocyclic isoxazoline derivatives are used in the production of veterinary compositions having antiparasitic action against ectoparasites for treating ectoparasite infection or invasion in animals.EFFECT: invention relates to a method of producing a compound of formulaand specific compounds used as intermediate compounds when producing the desired compounds.23 cl, 4 tbl, 9 ex |
