METHODS OF PRESERVING INJECTABLE PHARMACEUTICAL COMPOSITIONS COMPRISING A CYCLODEXTRIN AND A HYDROPHOBIC DRUG

摘要

The invention relates to injectable pharmaceutical compositions methods of use and formulation wherein the compositions comprise: one or more water soluble complexes each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation satisfying at least the B criteria as it applies to parenterals and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing satisfying the criteria for Category 1 (injectable) products.