发明名称 |
APROTININ DERIVED POLYPEPTIDE ANTIBODY CONJUGATES |
摘要 |
The present invention relates to protein conjugates comprising an aprotinin derived polypeptide which facilitates transport of the conjugate across the blood brain barrier and an antibody moiety that selectively binds a target within the CNS. The protein conjugates are further defined by the inclusion of a linker; by the number of polypeptides conjugated to each antibody moiety; by the positions at which the antibody moiety and the polypeptides are conjugated; and by the larger configuration of the conjugate (in which every polypeptide is linked only to the antibody moiety). Modified aprotinin derived polypeptides linker bound antibody moieties pharmaceutical compositions kits and methods of making and using the protein conjugates are also features of the invention. |
申请公布号 |
IN4294DEN2015(A) |
申请公布日期 |
2015.10.16 |
申请号 |
IN2015DELNP4294 |
申请日期 |
2015.05.20 |
申请人 |
ANGIOCHEM INC. |
发明人 |
TRIPATHY SASMITA;DEMEULE MICHEL;CURRIE JEAN CHRISTOPHE |
分类号 |
C07K19/00;A61K47/48;A61P35/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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