USE OF P2X PURINERGIC RECEPTOR AGONISTS TO ENHANCE INSULIN SECRETION IN PANCREATIC &bgr; CELLS

摘要

PROBLEM TO BE SOLVED: To provide new treatments and new effective pharmaceutical compounds for use as primary or adjuvant therapeutics.SOLUTION: This invention provides a method of screening for a compound compound/agent effective for increasing insulin secretion in a primate, comprising contacting a test compound with a P2X3 receptor and measuring the activity of the receptor, wherein an increase in activity of the receptor is indicative of a candidate compound effective for increasing insulin secretion.