GPR40 RECEPTOR AGONIST, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT

摘要

The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.

主权项

1. A compound of Formula (1), or pharmaceutically acceptable salts or isomers thereof: wherein, X represents C or N, Y represents C, N, C═O or C-halogen, Z represents C, N or O, Q represents O or NH, W represents C, N, C-alkyl or C-halogen, R1 represents H, alkyl, heteroalkyl, aryl, heterocycle, aryl-alkyl or heterocycle-alkyl, R2 represents H, alkyl, heteroalkyl or halogen, R3 represents H, alkyl or halogen, R4 represents H, O, alkyl or halogen, R5 represents H, alkyl, alkoxy, CN, heterocycle or C≡C-Me, R4 and R5 can be connected together to form 5- or 6-membered ring, R6 represents H or alkyl, and R5 and R6 can be connected together to form 3-membered ring.