| 主权项 |
1. A compound of the following formula (I): Wherein: A is aryl; B is selected from the group consisting of a chemical bond, —C1-6 alkylene-, —C1-6 alkylene-NR2—, —NR2—, and —(C═O)—; C is selected from the group consisting of a chemical bond, —(C═O)—, and —NR2—; R1 is independently selected from the group consisting of; (1) hydrogen, (2) —On—C1-6 alkyl where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (3) —On—C3-7 cycloalkyl where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (4) —On-aryl where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11, (5) —S—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (6) —S-aryl where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11; (7) —NH—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, and (8) —NH-aryl, where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11; wherein n is independently 0 or 1, when n is 0, a chemical bond is present in the place of —On—; R2 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4) —On—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (5) —On—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (6) —On—C2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R7, (7) —On-phenyl or —On-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R7, (8) —On-heterocyclyl, where the heterocyclyl is unsubstituted or substituted with one or more substituents independently selected from R7, (9) —(C═O)—NR8R9, (10) —NR8R9, (11) —S(O)2—NR8R9, (12) —NR8—S(O)2R9, (13) —S(O)t—R9, where t is 0, 1 or 2, (14) —NR8(C═O)R9, (15) —CN, and (16) —NO2; wherein n is independently 0 or 1, when n is 0, a chemical bond is present in the place of —On—; p is 1, 2, 3, or 4; when p is two or more than two, R2 may be same or different; R3 and R4 are independently hydrogen or C1-6 alkyl which is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, and —O—C1-6 alkyl; or R3 form a 3 to 7 membered ring with R4 which may contain nitrogen atom, oxygen atom, sulfur atom or double bond, wherein the 3 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydrogen, (2) hydroxyl, (3) halogen, (4) C1-6 alkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (5) C3-6 cycloalkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (6) —O—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, and (7) —O—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11; R5 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —On—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (4) —On—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R7, and (5) —On—C2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R7; wherein n is independently 0 or 1, when n is 0, a chemical bond is present in the place of —On—; R5 may be anywhere on the pyrazolopyridine ring; q is 1, 2 or 3; when q is two or more than two, R5 may be same or different; R6 is independently hydrogen, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C3-7 cycloalkyl, —NR8R9, heterocyclyl, aryl, aryl-C1-6 alkyl, or heterocyclyl-C1-6 alkyl, where the C1-6 alkyl, the C1-6 alkoxy, the C2-6 alkenyl, the C3-7 cycloalkyl, the heterocyclyl, the aryl, the aryl-C1-6 alkyl, or the heterocyclyl-C1-6 alkyl, is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, C1-6 alkyl, —O—C1-6 alkyl, —C3-7 cycloalkyl, —O—C3-7 cycloalkyl, hydroxyl-C1-6 alkoxy, —CN, —NR8R9, —(C═O)—R8, —(C═O)—NR8R9, —NR8—(C═O)—R9, —NR8—(C═O)—NR9R10, —NR8—(C═O)—OR9, —NR—S(O)2—R9, —NR8—S(O)2—NR9R10, and —S(O)2—R8; when B is —NR2— and C is —(C═O)—, R6 may form the 4-7 membered ring with R2; R7 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4) —(C═O)m—Ol—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (5) —Ol—(C1-3)perfluoroalkyl, (6) —(C═O)m—Ol—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (7) —(C═O)m—Ol—C2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R11, (8) —(C═O)m—Ol-phenyl or —(C═O)m—Ol-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R11, (9) —(C═O)m—Ol-heterocyclyl, where the heterocyclyl is unsubstituted or substituted with one or more substituents independently selected from R11, (10) —(C═O)—NR8R9, (11) —NR8R9, (12) —S(O)2—NR8R9, (13) —S(O)t—R8, where t is 0, 1 or 2, (14) —CO2H, (15) —CN, and (16) —NO2; wherein 1 is 0 or 1 and m is 0 or 1; when 1 is 0 or m is 0, a chemical bond is present in the place of —Ol— or —(C═O)m—, and when 1 is 0 and m is 0, a chemical bond is present in the place of —(C═O)m—Ol—; R8, R9, and R10 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, or aryl, which is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, C1-6 alkyl, —O—C1-6 alkyl, C3-7 cycloalkyl, and —O—C3-7 cycloalkyl; or R8 form a 4 to 7 membered ring with R9 which may contain nitrogen atom, oxygen atom, sulfur atom or double bond, wherein the 4 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydrogen, (2) hydroxyl, (3) halogen, (4) C1-6 alkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (5) C3-6 cycloalkyl, which is unsubstituted or substituted with one or more substituents independently selected from R11, (6) —O—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11, and (7) —O—C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11; R11 is independently selected from the group consisting of: (1) hydrogen, (2) hydroxyl, (3) halogen, (4) —C1-6 alkyl, which is unsubstituted or substituted with one or more halogen, (5) —C3-6 cycloalkyl, (6) —O—C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more halogen, (7) —O(C═O)—C1-6 alkyl, (8) —NH—C1-6 alkyl, (9) phenyl, (10) heterocyclyl, (11) —CN, and (12) —Si(C1-6 alkyl)3; k is 1 or 2; r is 0 or 1, when r is 0, a chemical bond is present in the place of —[O]r—; or a prodrug thereof or a pharmaceutically acceptable salt thereof. |
