发明名称 |
BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF |
摘要 |
This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. |
申请公布号 |
CA2948275(A1) |
申请公布日期 |
2015.10.15 |
申请号 |
CA20152948275 |
申请日期 |
2015.04.07 |
申请人 |
BOSTON PHARMACEUTICALS INC. |
发明人 |
ETTINGER, CATHERINE;KARNELL, JODI;DAMSCHRODER, MELISSA;CHOWDHURY, PARTHA;XIAO, XIAODONG;TSUI, PING;VARKEY, REENA;DRABIC, STACEY;CARTER, LAURA;HERBST, RONALD;DU, QUN;NAIMAN, BRIAN MICHAEL |
分类号 |
A61K39/395;C07K16/42 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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