ETP DERIVATIVES

摘要

Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.

主权项

1. A compound having the formula: wherein, p is 2, 3 or 4; R1 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33A, —NR34AR35A, —COOR33A, —CONR34AR35A, —NO2, —SR36A, —SOn1R34A, —SOn1OR34A, —SOn1NR34AR35A, —NHNR34AR35A, —ONR34AR35A, —NHC(O)NHNR34AR35A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R2 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33B, —NR34BR35B, —COOR33B, —CONR34BR35B, —NO2, —SR36B, —SOn2R34b, —SOn2OR34B, —SOn2NR34BR35B, —NHNR34BR35B, —ONR34BR35B, —NHC(O)NHNR34BR35B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33C, —NR34CR35C, —COOR33C, —CONR34CR35C, —NO2, —SR36C, —SOn3R34C, —SOn3OR34C, —SOn3NR34CR35C, —NHNR34CR35C, —ONR34CR35C, —NHC(O)NHNR34CR35C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33D, —NR34R35D, —COOR33D, —CONR34DR35D, —NO2, —SR36D, —SOn4R34D, —SOn4OR34D, —SOn4NR34DR35D, —NHNR34DR35D, —ONR34DR35D, —NHC(O)NHNR34DR35D, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R5 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33E, —NR34ER35E, —COOR33E, —CONR34ER35E, —NO2, —SR36E, —SOn5R34E, —SOn5OR34E, —SOn5NR34ER35E, —NHNR34ER35E, —ONR34ER35E, —NHC(O)NHNR34ER35E, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R6 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33F, —NR34FR35F, —COOR33F, —CONR34FR35F, —NO2, —SR36F, —SOn6R34F, —SOn6OR34F, —SOn6NR34FR35F, —NHNR34FR35F, —ONR34FR35F, —NHC(O)NHNR34FR35F, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R16 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33G, —NR34GR35G, —COOR33G, —CONR34GR35G, —NO2, —SR36G, —SOn7R34G, —SOn7OR34G, —SOn7NR34GR35G, —NHNR34GR35G, —ONR34GR35G, —NHC(O)NHNR34GR35G, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R18 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR33H, —NR34HR35H, —COOR33H, —CONR34HR35H, —NO2, —SR36H, —SOn8R34H, —SOn8OR34H, —SOn8NR34HR35H, —NHNR34HR35H, —ONR34HR35H, —NHC(O)NHNR34HR35H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R33A, R34A, R35A, R36A, R33B, R34B, R35B, R36B, R33C, R34C, R35C, R36C, R33D, R34D, R35D, R36D, R33E, R34E, R35E, R36E, R33F, R34F, R35F, R36F, R33G, R34G, R35G, R36G, R33H, R34H, R35H, and R36H are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n1, n2, n3, n4, n5, n6, n7, and n8 are independently 1 or 2.