N-(PIPERIDIN-4-YL)BENZO[B]THIOPHENECARBOXYAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING UROTENSIN-II RECEPTOR ACTIVITY-RELATED DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT

摘要

The present invention relates to a N-(piperidin-4-yl)benzo[b] thiophenecarboxyamide derivative, a preparation method therefor, and a pharmaceutical composition for preventing or treating urotensin-II receptor activity-related diseases, comprising the same as an active ingredient. The N-(piperidin-4-yl)benzo[b]thiophenecarboxyamide derivative acts as an antagonist for the urotensin-II receptor, and thus can be usefully used for preventing or treating urotensin-II receptor activity-related diseases such as congestive heart failure, cardiac ischemia, myocardial infarction, cardiac hypertrophy, cardiac fibrosis, coronary artery disease, arteriosclerosis, hypertension, asthma, renal failure, diabetes, vascular inflammation, neurodegenerative diseases, stroke, pain, depression, psychosis and cancer.