COMPOSITIONS AND METHODS FOR DISTRACTION OSTEOGENESIS

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for distraction osteogenesis.SOLUTION: The invention relates to compositions and methods to be used in osteodistraction procedures. In one embodiment, a method for stimulating osteogenesis during and/or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix, and applying the composition at least one bone distraction site. One embodiment of the invention is use of a composition comprising a PDGF solution and a biocompatible matrix in preparation of medicaments useful for stimulating osteogenesis in the bone distraction procedures, where the solution is disposed in the biocompatible matrix.