FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide factor VIII compositions and methods of making and using the same.SOLUTION: The present invention relates to novel coagulation factor VIII fusion protein compositions and the use thereof. Specifically, the compositions provided herein are particularly used for the treatment or improvement of a condition associated with hemophilia A, deficiencies of factor VIII, bleeding disorders and coagulopathies. In one aspect, the present invention provides compositions of isolated fusion proteins comprising a factor VIII (FVIII) and one or more extended recombinant polypeptides (XTEN) wherein the fusion protein exhibits procoagulant activity.