ANTIBODIES AGAINST INFLUENZA VIRUS AND METHODS OF USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide human scFv antibodies and monoclonal antibodies that neutralize an influenza virus.SOLUTION: The invention provides an isolated monoclonal anti-influenza hemagglutinin protein antibody or fragment thereof. The antibody has a VH amino acid sequence encoded by the VH germline gene IGHV1-69*01, and amino acids at positions as follows: a) a valine at 27; b) threonine at 28; c) serine at 30; d) serine at 31; e) methionine at 54; f) phenylalanine at 55; g) threonine at 58; h) proline at 100; i) serine at 101; j) tyrosine at 102; k) isoleucine at 103 and serine at 105.