发明名称 |
TUBULYSIN DERIVATIVES |
摘要 |
Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone or as drug conjugates with antibodies are provided. The tubulysin derivatives consist of a tetrapeptide scaffold comprising methyl and ethyl substituted piperidines. The tubulysin conjugates further comprise monoclonal antibody via succinimide linkers. |
申请公布号 |
CA2945318(A1) |
申请公布日期 |
2015.10.15 |
申请号 |
CA20152945318 |
申请日期 |
2015.04.10 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
GINGIPALLI, LAKSHMAIAH;TOADER, DORIN;WANG, FENGJIANG |
分类号 |
C07D277/30;A61K31/426;A61K31/427 |
主分类号 |
C07D277/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|