CRYSTALLINE FORMS OF PYRROLOQUINOLINE QUINONE DISODIUM SALT

摘要

The present invention relates to crystalline forms of pyrroloquinoline quinone disodium salt. The present invention provides crystalline Form A and crystalline Form B of pyrroloquinoline quinone disodium salt, and the methods and uses for the preparation thereof. The X-ray powder diffraction patterns of crystalline Form A and crystalline Form B are as shown by FIG. 1 and FIG. 5, respectively. The crystalline forms of the present invention have low moisture absorption and high stability, as well as excellent use and storage performances.

主权项

1. A pyrroloquinoline quinone disodium salt crystalline Form A, which shows diffraction peaks at the following 2θ angles in an X-ray powder diffraction pattern obtained by Cu-K α radiation: 9.6±0.2°, 11.6±0.2°, 14.9±0.2°, 16.0±0.2°, 18.8±0.2°, 19.4±0.2°, 20.4±0.2°, 21.9±0.2°, 22.7±0.2°, 23.2±0.2°, 25.6±0.2°, 33.7±0.2°, 35.0±0.2°, 35.8±0.2°, 36.7±0.2°, 38.0±0.2°, and 38.6±0.2°.