发明名称 |
Composition comprised of antigen linked to a TNF SuperFamily ligand |
摘要 |
The invention provides fusion proteins comprising antigens of infectious disease agents and cancer cells linked to multiple-trimer forms of TNF SuperFamily (TNFSF) ligands. The TNFSFs serve as vaccine adjuvants for increasing the immune response to the antigens. In particular, a fusion polypeptide strand that self-assembles inside cells into a multiple-trimer form of CD40 ligand (CD40L, TNFSF5) is provided. Other similar fusion proteins are also disclosed. The fusion proteins can be delivered to a host as isolated proteins, as nucleic acids used directly in DNA vaccination or carried and expressed by a viral vector such as adenovirus. In addition to use as a vaccine to prevent or ameliorate disease caused by an infectious agent, compositions of the invention may be used for the treatment of ongoing infection or for cancer immunotherapy. |
申请公布号 |
AU2014233114(A1) |
申请公布日期 |
2015.10.15 |
申请号 |
AU20140233114 |
申请日期 |
2014.03.16 |
申请人 |
STONE, GEOFFREY;KORNBLUTH, RICHARD |
发明人 |
STONE, GEOFFREY W.;KORNBLUTH, RICHARD S. |
分类号 |
C07K14/705;A61K39/00;C12N5/0781;C12N5/0784;C12N5/0786 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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