1-(5-TERT-BUTYL-2-PHENYL-2H-PYRAZOL-3-YL)-3-[2-FLUORO-4-(1-METHYL- 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-7-YLOXY)-PHENYL]-UREA AND RELATED COMPOUNDS AND THEIR USE IN THERAPY

摘要

PROBLEM TO BE SOLVED: To provide alternative compounds which provide unexpected activity (e.g., activity against mutant RAS cancer) as compared to one or more of structurally-related known compounds.SOLUTION: This invention provides compounds of the formula (I) which, inter alia, are useful in the treatment of cancer, e.g., cancer characterized by (e.g., driven by) mutant RAS ("mutant RAS cancer").