HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

摘要

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

主权项

1. A compound having a structure of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein n is 1 or 2; R1 is alkyl or alkoxy; R2 is absent, hydrogen, alkyl, or alkoxy; R3 is hydrogen, alkyl, or cycloalkyl; and X1 and X2 are each independently CH, CH2, NR3, or O.