AMINOIMIDAZOPYRIDAZINES

摘要

The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.;

主权项

1. A compound of general formula (I): in which:represents a:group;
wherein * indicates the point of attachment of said groups with the rest of the molecule; R1 represents a C3-C6-cycloalkyl or a —(CH2)-C3-C6-cycloalkyl group which is substituted one or more times with a hydroxy group and which is optionally substituted with one or more substituents selected, independently from each other, from: a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 3- to 6-membered heterocycloalkyl which is connected as spiro; aryl- optionally substituted one or more times, independently from each other, with an R substituent; aryl-C1-C6-alkyloxy- optionally substituted one or more times, independently from each other, with an R substituent; heteroaryl- optionally substituted one or more times, independently from each other, with an R substituent; —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OH, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S— group; R2 represents a hydrogen atom; R3 represents a substituent selected from: a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, C3-C6-cycloalkoxy-, C3-C6-cycloalkyl-C1-C3-alkoxy-, —OC(═O)R′, —SH, C1-C3-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group; R4 represents a substituent selected from: a hydrogen atom, a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl- optionally substituted one or more times, independently from each other, with an R substituent; heteroaryl- optionally substituted one or more times, independently from each other, with an R substituent; —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group; R represents a substituent selected from: a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C3-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″group; R′ and R″ represent, independently from each other, a substituent selected from: C1-C6-alkyl-, C1-C6-haloalkyl-; n represents an integer of 0, 1, 2 or 3; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.