TRICYCLIC COMPOUND

摘要

The invention provides a method of activating PPAR γ and a method of treating or preventing a disease associated with PPAR γ by administering a tricyclic compound having a PPAR γ agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:;

主权项

1. A tricyclic compound represented by the general formula (I) wherein Z represents a single bond, CH2, CH2CH2, CH═CH, O, S, CH2O, OCH2, CH2S(O), or S(O)nCH2 wherein n is an integer of 0 to 2, Y represents a hydrogen atom, lower alkyl optionally having substituent(s), lower alkoxy optionally having substituent(s), cycloalkyl optionally having substituent(s) or halogen, X represents a hydrogen atom, lower alkyl, cyano, halogen, hydroxymethyl, aminomethyl, carboxy, lower alkoxycarbonyl optionally having substituent(s), carbamoyl, lower alkylcarbamoyl optionally having substituent(s), di-lower alkylcarbamoyl optionally having substituent(s), arylcarbamoyl optionally having substituent(s), lower alkylsulfonylcarbamoyl optionally having substituent(s), arylsulfonylcarbamoyl optionally having substituent(s), cycloalkylsulfonylcarbamoyl optionally having substituent(s), lower alkylaminosulfonylcarbamoyl optionally having substituent(s), aliphatic heterocyclyl carbonyl optionally having substituent(s), lower alkanoylaminomethyl optionally having substituent(s), lower alkylsulfonylaminomethyl optionally having substituent(s), an aliphatic heterocyclic group optionally having substituent(s) or an aromatic heterocyclic group optionally having substituent(s), A represents aryl optionally having substituent(s) or an aromatic heterocyclic group optionally having substituent(s), B and C are the same or different and each represents an aromatic carbocycle or aromatic heterocycle, R4, R5, R6, R7, R8 and R9 are the same or different and each represents a hydrogen atom, halogen, hydroxy, lower alkoxy or lower alkyl, V represents a single bond, O, NRA wherein RA represents a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), lower alkylcarbamoyl optionally having substituent(s) or lower alkylsulfonyl optionally having substituent(s), or S, and R10 and R11 are the same or different and each represents a hydrogen atom or lower alkyl, or a pharmaceutically acceptable salt thereof.