| 摘要 |
Provided are quinazolinone compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed. |
| 主权项 |
1. A compound of formula (I):or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein:R1 is hydrogen;each of R2, R3, and R4 is independently: hydrogen; halo; —(CH2)nOH; (C1-C6)alkyl, optionally substituted with one or more halo; (C1-C6)alkoxy, optionally substituted with one or more halo; or
—(CH2)nNHRa, wherein Ra is:
hydrogen;(C1-C6)alkyl, optionally substituted with one or more halo;—(CH2)n-(6 to 10 membered aryl);—C(O)—(CH2)n-(6 to 10 membered aryl) or —C(O)—(CH2)n-(6 to 10 membered heteroaryl), wherein the aryl or heteroaryl is optionally substituted with one or more of: halo; —SCF3; (C1-C6)alkyl, said alkyl itself optionally substituted with one or more halo; or (C1-C6)alkoxy, said alkoxy itself optionally substituted with one or more halo;—C(O)—(C1-C8)alkyl, wherein the alkyl is optionally substituted with one or more halo;—C(O)—(CH2)n—(C3-C10-cycloalkyl);—C(O)—(CH2)n—NRbRc, wherein Rb and Rc are each independently:
hydrogen;(C1-C6)alkyl, optionally substituted with one or more halo;(C1-C6)alkoxy, optionally substituted with one or more halo; or6 to 10 membered aryl, optionally substituted with one or more of: halo;
(C1-C6)alkyl, itself optionally substituted with one or more halo; or(C1-C6)alkoxy, itself optionally substituted with one or more halo;—C(O)—(CH2)n—O—(C1-C6)alkyl; or—C(O)—(CH2)n—O—(CH2)n—(6 to 10 membered aryl); ortwo of R1-R4 together can form a 5 or 6 membered ring, optionally substituted with one or more of: halo; (C1-C6)alkyl, optionally substituted with one or more halo; and (C1-C6)alkoxy, optionally substituted with one or more halo;R5 is: hydrogen; —(CH2)OH; phenyl; —O—(C1-C6)alkyl; or (C1-C6)alkyl, optionally substituted with one or more halo;R6 is: hydrogen; or (C1-C6)alkyl, optionally substituted with one or more halo; andn is 0, 1, or 2. |
