| 主权项 |
1. A method for treatment of an estrogen-related medical disorder, the method comprising administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of hydrogen, alkyl, —SO3Rx1, —PO3Ry1Rz1, and —C(═O)Ra; R2 is selected from the group consisting of halo and —OR3; R3 is selected from the group consisting of hydrogen, alkyl, —SO3Rx1, —PO3Ry1Rz1, and —C(═O)Ra; A1 is H, alkyl, —Rb1, —ORb2, or —C(═O)Rb3; Rb1, Rb2, and Rb3 are each independently selected from the group consisting of is alkyl, cycloalkyl, and phenyl substituted with 1, 2, or 3 substituents independently selected from halo and —OR4; R4 is selected from the group consisting of hydrogen, alkyl, —SO3Rx1, —PO3Ry1Rz1, and —C(═O)Ra; Ra, at each occurrence, is independently selected from the group consisting of —OH and alkyl; and Rx1, Ry1 and Rz1 are, at each occurrence, independently selected from the group consisting of hydrogen and a pharmaceutically acceptable cation; provided that the compound of formula (I) contains at least one group selected from —OR3 and —OR4; provided that 2-(4-fluorophenyl)-3-(4-hydroxyphenoxyl)benzo[b]thiophen-6-ol is excluded from the compound of formula (I). |
