发明名称 |
Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
摘要 |
<p>The present invention relates to compounds of formula (I) for their use in the treatment and/or prevention of auto-immune or auto-immune related diseases, cancer, viral infections, and central nervous system diseases and disorders, by inhibiting human dehydroorate dehydrogenase (DHODH):
Wherein R 1 , R 2 , R 3 , R 4 and Ar are as defined in claim 1.</p> |
申请公布号 |
EP2929883(A1) |
申请公布日期 |
2015.10.14 |
申请号 |
EP20140305516 |
申请日期 |
2014.04.08 |
申请人 |
INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
JANIN, YVES LOUIS;GUILLOU, SANDRINE;LUCAS-HOURANI, MARIANNE;MUNIER-LEHMANN, HÉLÈNE;NOEL, ANNE;SALANOUVE, ELISE;TANGY, FRÉDÉRIC;VIDALAIN, PIERRE-OLIVIER |
分类号 |
A61K31/4439;A61K31/501;A61K31/506;A61P31/12;C07D401/04;C07D403/04 |
主分类号 |
A61K31/4439 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|