PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS
摘要
The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.
申请公布号
EP2928472(A1)
申请公布日期
2015.10.14
申请号
EP20130860921
申请日期
2013.12.04
申请人
MERCK SHARP & DOHME CORP.
发明人
ITOH, TETSUJI;JEON, INGYU;MANGION, IAN;QIAN, GANG;SHERRY, BENJAMIN, D.;GAUTHIER, DONALD, R.;CAO, YANG