<p>The invention is directed to 6-(4-pyrimidinyl)-1H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1-R4 are defined herein. The compounds of the invention axe inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.</p>
申请公布号
ES2548141(T3)
申请公布日期
2015.10.14
申请号
ES20090828129T
申请日期
2009.11.18
申请人
GLAXOSMITHKLINE LLC
发明人
AXTEN, JEFFREY MICHAEL;BLACKLEDGE, CHARLES WILLIAM;BRADY, GERALD PATRICK;FENG, YANHOUG G.;GRANT, SETH W.;MEDINA, JESUS RAHUL;MILLER, WILLIAM H.;ROMERIL, STUART P.