Inhibitors of beta integrin-G protein alpha subunit binding interactions

摘要

Provided herein are compounds that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.

主权项

1. A method of inhibiting thrombosis in a subject in need thereof comprising administering to the subject a peptide, or a conjugate or a micelle comprising the peptide, in an amount effective to inhibit thrombosis, wherein the peptide comprises an amino acid sequence
Phe Xaa1 Xaa2 Glu Xaa3 Xaa4 wherein Xaa1 is Glu or Gln and Xaa2 is Glu, Lys, Ser, or Ala, wherein Xaa3 is Lys, Arg, or Gln and Xaa4 Met, Leu, Ala, Ser, or Gln, wherein the peptide is a 6-mer, 7-mer, 8-mer, 9-mer-10-mer, 11-mer, 12-mer, 13-mer, or 14-mer.