Tripeptides that down regulate the activity of plasma membrane transporters including sodium-D-glucose cotransporter SgIt1

摘要

A regulatory protein RS1 fragment or a nucleic acid molecule encoding the regulatory protein RS1 fragment for the preparation of a pharmaceutical composition, food and/or food supplements for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein the RS1 fragment is characterized in comprising at least the amino acid sequence Q-C-P Glutamine-Cysteine-Proline) or derivatives thereof, is provided. Also provided is a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis comprising administering a pharmaceutically active amount of a regulatory protein RS1 fragment or a nucleic acid molecule encoding a regulatory protein RS1 fragment, wherein the RS1 fragment comprises at least the amino acid sequence Q-C-P or derivatives thereof.

主权项

1. A method for the treatment of obesity, hypercholesterolemia, diabetes or hyperglycaemia, comprising administering to a patient in need of such treatment a therapeutically effective amount of a peptide consisting of an amino acid sequence selected from the group consisting of:(a)Q-C-P;(b)Q-N-E-Q-C-P(SEQ ID NO: 18);(c)Q-C-P-Q-V-S(SEQ ID NO: 19);(d)Q-N-E-Q-C-P-Q-V-S(SEQ ID NO: 17);(e)Q-S-P;(f)Q-P-P;(g)Q-T-P.