| 发明名称 |
Pulmonary delivery of a fluoroquinolone |
| 摘要 |
A composition for pulmonary administration comprises a fluoroquinolone betaine, such as ciprofloxacin betaine, and an excipient. In one version, the particles have a mass median aerodynamic diameter from about 1 μm to about 5 μm, and the fluoroquinolone has a half life in the lungs of at least 1.5 hours. The composition is useful in treating an endobronchial infection, such as Pseudomonas aeruginosa, and is particularly useful in treating cystic fibrosis. |
| 申请公布号 |
US9155732(B2) |
申请公布日期 |
2015.10.13 |
| 申请号 |
US201414457162 |
申请日期 |
2014.08.12 |
| 申请人 |
Novartis AG |
发明人 |
Weers Jeffry;Tarara Thomas |
| 分类号 |
A61K9/14;A61K31/47;A61K31/496;A61P11/00;A61P31/04;A61K9/00;A61M15/00 |
主分类号 |
A61K9/14 |
| 代理机构 |
|
代理人 |
Tucker Guy H |
| 主权项 |
1. A powder composition for pulmonary administration in a unit dose receptacle, the powder composition comprising:
particles comprising a ciprofloxacin betaine hydrate and an excipient, wherein the particles have a mass median aerodynamic diameter from about 1 μm to about 5 μm and wherein the ciprofloxacin has a half life in the lungs of at least 1.5 hours, and wherein the composition has a rugosity of from about 3 to 10. |
| 地址 |
Basel CH |
