| 发明名称 | Amino acid sequences which enhance peptide conjugate solubility | ||
| 摘要 | The present invention provides peptide conjugates having improved solubility as well as increased secretion during cell based production, as well as methods of utilizing such peptides. The peptide conjugates include a short peptide domain defined by the amino acid sequence AGIH (SEQ ID NO: 8) and may include a biologically active molecule useful in intracellular and intranuclear transport of the biologically active molecule to treat various disorders and diseases. | ||
| 申请公布号 | US9155801(B2) | 申请公布日期 | 2015.10.13 |
| 申请号 | US201013322914 | 申请日期 | 2010.05.27 |
| 申请人 | The United States Government as Represented by the Department of Veterans Affairs | 发明人 | Weisbart Richard H. |
| 分类号 | A61K47/48;C07K16/44;C12N15/62 | 主分类号 | A61K47/48 |
| 代理机构 | DLA Piper LLP (US) | 代理人 | DLA Piper LLP (US) |
| 主权项 | 1. A peptide-antibody conjugate comprising, a peptide of about 4 to 50 amino acid residues comprising the amino acid sequence AGIH (SEQ ID NO: 8); and mAb 3E10, or functional fragment thereof, having a binding specificity as produced by a hybridoma having ATCC accession number PTA 2439, wherein the peptide is conjugated to the N-terminus of the antibody or functional fragment thereof. | ||
| 地址 | Washington DC US | ||