发明名称 |
MicroRNA compounds and methods for modulating miR-122 |
摘要 |
Described herein are compositions and methods for the inhibition of miR-122 activity. The compositions have certain nucleoside modifications that yield potent inhibitors of miR-122 activity. The compounds may comprise conjugates to facilitate delivery to the liver. The compositions may be administered to subjects infected with hepatitis C virus, as a treatment for hepatitis C virus and related conditions. |
申请公布号 |
US9157083(B2) |
申请公布日期 |
2015.10.13 |
申请号 |
US201414577481 |
申请日期 |
2014.12.19 |
申请人 |
Regulus Therapeutics Inc. |
发明人 |
Bhat Balkrishen;Hogan Daniel |
分类号 |
C12N15/11;C07H19/00;C12N15/113;A61K31/7125;A61K47/48 |
主分类号 |
C12N15/11 |
代理机构 |
McNeill Baur PLLC |
代理人 |
McNeill Baur PLLC |
主权项 |
1. A compound comprising a modified oligonucleotide having the structure:
AEMeCEAEMeCEMeCEAETETGUSCSACSACSTCSCS (SEQ ID NO: 4) wherein the superscript “Me” indicates 5-methylcytosine; nucleosides not followed by a subscript are β-D-deoxyribonucleosides; nucleosides followed by a subscript “E” are 2′-MOE nucleosides; nucleosides followed by a subscript “S” are S-cEt nucleosides; and each internucleoside linkage is a phosphorothioate internucleoside linkage. |
地址 |
San Diego CA US |