Pharmaceutical composition and method for regenerating myofibers in the treatment of muscle injuries

摘要

A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of Formula (I). The active ingredient compound is capable of (a) increasing viability of myogenic precursor cells to enable said precursor cells to survive through an absolute ischemic period; (b) reconstituting a damaged blood supply network in said heart region where said injured muscle is located; and (c) enhancing cardiomyogenic differentiation efficiency of said precursor cells down cardiac linage, said steps being performed simultaneously or in any particular order.;

主权项

1. A method of regenerating myocytes or myocardia in the heart of a mammalian subject suffering from an injured heart muscle, comprising a step of administering an effective amount of a compound in a substantially pure form isolated from natural resources or obtained by chemical synthesis of the following formula: wherein R1 is H orto said subject.