| 发明名称 | Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870 | ||
| 摘要 | NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other. | ||
| 申请公布号 | US9156894(B2) | 申请公布日期 | 2015.10.13 |
| 申请号 | US201313845305 | 申请日期 | 2013.03.18 |
| 申请人 | GlaxoSmithKline Biologicals SA | 发明人 | Masignani Vega;Scarselli Maria;Rappuoli Rino;Pizza Mariagrazia;Giuliani Marzia Monica |
| 分类号 | A61K39/095;C12P21/04;C07K14/22;A61K38/16 | 主分类号 | A61K39/095 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A hybrid polypeptide comprising an amino acid sequence having at least 85% identity to SEQ ID NO: 36. | ||
| 地址 | Rixensart BE | ||