17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzylidene derivatives, methods for the production thereof and use thereof for treating diseases

摘要

The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene 11-benzylidene derivatives of the formula I, in which Y and X are each as defined in the claims and the description,;
to a process for preparation thereof and to the use thereof as medicaments.

主权项

1. 17-Hydroxy-17-pentafluoroethylestra-4,9(10)-diene 11-benzylidene derivatives of the general formula (I) in which Y is a —CR1═CHR2 or a —CR1═NR3 group, each of which is joined to the phenyl ring in the meta (m) or para (p) position, in which R1 is hydrogen or a C1-C10-alkyl radical, R2 is hydrogen, a C1-C10-alkyl, C2-C10-alkenyl, aryl, C7-C20-aralkyl, C1-C10-acyl, CO2R4, CN, CH═CH—CO2R4, CH2CH(CO2R4)2, CH2CH(CN)2 or a CH2NHCONHR5 radical and R3 is a C1-C10-alkyl, O—(CH2)n—COOR4, O—CH2-aryl, aryl, C7-C20-aralkyl or a CH2CO2R4 radical in which R4 is hydrogen, or a C1-C10-alkyl group and R5 is a C1-C10-alkyl, C2-C10-alkenyl, aryl, C7-C20-aralkyl, (CH2)nCO2R4 group where n=1 or 2 and R4 is defined as specified, or R5 is agroup and
X is oxygen, an NOR6 or an NNHSO2R6 group, in which R6 is hydrogen, a C1-C10-alkyl, aryl or C7-C20-aralkyl radical, or a salts, or α-, β- or γ-cyclodextrin clathrate thereof.