| 发明名称 | Treatment of chronic progressive heart failure | ||
| 摘要 | The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188). | ||
| 申请公布号 | US9155758(B2) | 申请公布日期 | 2015.10.13 |
| 申请号 | US200712309803 | 申请日期 | 2007.08.01 |
| 申请人 | PHRIXUS PHARMACEUTICALS, INC. | 发明人 | Markham Bruce Edward |
| 分类号 | A61K31/77;A61K31/765 | 主分类号 | A61K31/77 |
| 代理机构 | Honigman Miller Schwartz and Cohn LLP | 代理人 | Honigman Miller Schwartz and Cohn LLP ;Alberdi Fernando;O'Brien Jonathan P. |
| 主权项 | 1. A method of treating systolic dysfunction in a systolic heart failure subject by decreasing left ventricular end-diastolic pressure (LVEDP) and increasing left ventricular ejection fraction (LVEF) without significantly increasing left ventricular end systolic volume, comprising administering to the subject in need thereof a therapeutically effective amount of a Poloxamer-188 ranging from greater than 4.6 mg/kg to 460 mg/kg. | ||
| 地址 | Ann Arbor MI US | ||