发明名称 | Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with type B peptide | ||
摘要 | A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term administration of non-specific immunosuppressive drugs. | ||
申请公布号 | US9155787(B2) | 申请公布日期 | 2015.10.13 |
申请号 | US201414540452 | 申请日期 | 2014.11.13 |
申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | Jiang Hong;Chess Leonard |
分类号 | A61K39/395;C12N5/10;A61K38/17;A61K39/00;A61K45/06;C07K16/28;A61K35/15 | 主分类号 | A61K39/395 |
代理机构 | Ascenda Law Group PC | 代理人 | Ascenda Law Group PC |
主权项 | 1. A method for preventing rejection of a tissue transplanted from a donor subject into a recipient subject comprising: a) administering to the recipient subject, prior to transplantation of the tissue, (i) a plurality of peripheral blood mononuclear cells (PBMCs) from the donor subject, wherein the PBMCs have been irradiated and do not proliferate in vivo, and (ii) an anti-CD40 ligand (anti-CD40L) antibody; and b) administering to the recipient subject, subsequent to transplantation of the tissue, (i) dendritic cells loaded with a type B self peptide, or (ii) a membrane-bound, HLA-E-bearing composition loaded with a type B peptide, wherein the type B self peptide comprises the amino acid sequence set forth in SEQ ID NO: 1. | ||
地址 | New York NY US |