Anti-TNF-α therapy for the mucopolysaccharidoses and other lysosomal disorders

摘要

The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-TNF-α therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-TNF-α therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-TNF-α therapy.

主权项

1. A method of treating a subject with a lysosomal storage disorder, said method comprising:
selecting a subject with a lysosomal storage disorder and administering to the selected subject an agent for an enzyme replacement therapy, and an agent for an anti-TNF-α treatment under conditions effective to treat the lysosomal storage disorder in the selected subject.