Composition of dialysis liquid comprising crystallisation inhibitor substances

摘要

This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallization.

主权项

1. A method to treat decreased excretory renal function in a subject in need thereof comprising administering to the subject:
(a) a dialysis liquid comprising a crystallization inhibitory substance wherein (i) the crystallization inhibitory substance is chosen from inositol phosphate, bisphosphonate, their pharmaceutically acceptable salts, and combinations thereof, (ii) the crystallization inhibitory substance maintains, in the body of the subject, an effective physiological concentration of at least one substance that contributes to regulate at least one of physiological and pathological crystallization and calcification processes in said subject, and (iii) the composition has a dose of inositol phosphate and/or any of the pharmaceutical acceptable salts thereof between 1 nmol/kg and 0.1 mol/kg of body weight of the subject; or, (b) an intravenous composition comprising at least one of inositol phosphate and any of its pharmaceutically acceptable salts, in a form adapted for intravenous administration, wherein the composition has a dose of inositol phosphate and/or any of the pharmaceutical acceptable salts thereof between 1 nmol/kg and 0.1 mol/kg of body weight of the subject; or, (c) a preparation comprising (i) a composition that comprises crystallization inhibitory substances selected from among inositol phosphate, bisphosphonate, their pharmaceutically acceptable salts and any combinations thereof, and (ii) a dialysis liquid administered to said subject separately, simultaneously or sequentially from said composition, wherein the composition has a dose of inositol phosphate and/or any of the pharmaceutical acceptable salts thereof between 1 nmol/kg and 0.1 mol/kg of body weight of the subject; or, (d) combinations thereof.