| 发明名称 | Humanized IL-15 animals | ||
| 摘要 | Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or human IL-15 protein. | ||
| 申请公布号 | US9155290(B2) | 申请公布日期 | 2015.10.13 |
| 申请号 | US201414514454 | 申请日期 | 2014.10.15 |
| 申请人 | REGENERON PHARMACEUTICALS, INC. | 发明人 | Rojas Jose F.;Lai Ka-Man Venus;Murphy Andrew J. |
| 分类号 | A01K67/027;C12N15/85;C07K14/54 | 主分类号 | A01K67/027 |
| 代理机构 | Scully, Scott, Murphy & Presser, P.C. | 代理人 | Scully, Scott, Murphy & Presser, P.C. ;Miyamoto Neil |
| 主权项 | 1. A genetically modified mouse whose genome comprises a replacement at an endogenous mouse IL-15 locus of a mouse genomic segment comprising sequences of mouse exons 3, 4, 5 and 6 coding for a mature mouse IL-15 polypeptide with a human genomic segment comprising human IL-15 exons coding for a mature human IL-15 polypeptide to form a humanized IL-15 gene, wherein the human IL-15 exons in said human genomic segment consist of human exons 3, 4, 5 and 6, wherein the humanized IL-15 gene is under control of endogenous mouse IL-15 upstream regulatory elements at the endogenous mouse IL-15 locus, and wherein the genetically modified mouse comprises a human IL-15 polypeptide in serum following treatment of said mouse with Poly I:C. | ||
| 地址 | Tarrytown NY US | ||