发明名称 Diagnostic antibody assay
摘要 Diagnostic assays for the diagnosis of amyloidosis, in particular, Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
申请公布号 US9156907(B2) 申请公布日期 2015.10.13
申请号 US201113252929 申请日期 2011.10.04
申请人 PROBIODRUG AG 发明人 Demuth Hans-Ulrich;Schilling Stephan;Kleinschmidt Martin;Gans Kathrin;Reisenauer-Schaupp Anita;Rahfeld Jens-Ulrich;Kampfer Sonja
分类号 G01N33/577;G01N33/532;G01N33/543;C07K16/18;G01N33/68 主分类号 G01N33/577
代理机构 Dentons US LLP 代理人 Dentons US LLP
主权项 1. A method for detecting an Aβ peptide or variants thereof comprising: contacting an antibody that binds to an Aβ peptide or variant thereof and a sample potentially comprising an Aβ peptide or variants thereof; and detecting binding of the antibody and the Aβ peptide or variant thereof; wherein the antibody comprises (i) a light chain comprising a variable part, the variable part of the light chain of said antibody comprising a polypeptide (a) encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO: 49, SEQ ID NO: 53, SEQ ID NO: 57, and SEQ ID NO: 61 or(b) having an amino acid sequence selected from the group consisting of SEQ ID NO: 50, SEQ ID NO: 54, SEQ ID NO: 58, and SEQ ID NO: 62; or(ii) a heavy chain comprising a variable part; the variable part of the heavy chain of said antibody comprising a polypeptide (a) encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO: 51, SEQ ID NO: 55, SEQ ID NO: 59, and SEQ ID NO: 63 or(b) having an amino acid sequence selected from the group consisting of SEQ ID NO: 52, SEQ ID NO: 56, SEQ ID NO: 60, and SEQ ID NO: 64.
地址 Halle (Saale) DE