Nanostructured material formulated with bone cement for effective antibiotic delivery

摘要

This invention uses mesoporous silica nanoparticles and other nanostructured materials to formulate polyacrylate-based bone cement for achieving an enhanced and controlled elution of active ingredients such as antibiotics. This invention overcomes the limitation of low antibiotic release from commercial polyacrylate-based bone cements using for example, PMMA. In certain aspects, the formulation enables a sustained release of antibiotics from the bone cement over a period of 80 days and achieves 70% of total drug release, whereas the commercial antibiotic bone cement (e.g., SmartSet GHV) only releases about 5% of the antibiotics on the first day and subsequently an almost negligible amount. In addition, the mechanical properties of our formulated bone cements are well retained. The inventive bone cement exhibits good antibacterial properties and has very low cytotoxicity to mouse fibroblast cells.

主权项

1. A bone cement, the bone cement comprising:
a polyacrylate; and an active pharmaceutical ingredient, wherein the active pharmaceutical ingredient is an antibiotic and is disposed within mesoporous silica nanoparticles; wherein the mesoporous silica nanoparticle content is from 6 to about 10% w/w; and wherein the mesoporous silica nanoparticles form a diffusion network.