| 发明名称 |
Short beta-defensin-derived peptides |
| 摘要 |
The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention further provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. |
| 申请公布号 |
US9155780(B2) |
申请公布日期 |
2015.10.13 |
| 申请号 |
US201013148376 |
申请日期 |
2010.02.10 |
| 申请人 |
Yeda Research and Development Co. Ltd. |
发明人 |
Lapidot Tsvee;Kalinkovich Alexander;Fridkin Matityahu |
| 分类号 |
A61K38/08;C07K7/06;A61K38/17;A61K38/12;C07K14/47 |
主分类号 |
A61K38/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for elevating the levels of hematopoietic cells in peripheral blood of a subject in need thereof, comprising administering to the subject an effective amount of the isolated non-cyclized peptide selected from the group consisting of: (a) RGRKCCRRKK (TL-1, SEQ ID NO: 1); and (b) SGRKCCRKKK (AK-1, SEQ ID NO: 2). |
| 地址 |
Rehovot IL |
