| 发明名称 |
Treatment of sleep disturbances |
| 摘要 |
The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet, or alternatively as a soft gelatin capsule composition, to prevent interaction between the active ingredients. |
| 申请公布号 |
US9155718(B2) |
申请公布日期 |
2015.10.13 |
| 申请号 |
US201414504159 |
申请日期 |
2014.10.01 |
| 申请人 |
Wyeth LLC |
发明人 |
Cook Graham D.;Koch Todd S.;Giamalva David H.;Bianco Justin;Fort James J.;Doyle Geraldine;Cooper Steven |
| 分类号 |
A61K31/192;A61K31/138;A61K31/137;A61K9/24;A61K9/48 |
主分类号 |
A61K31/192 |
| 代理机构 |
|
代理人 |
Gold Jeffrey M.;Reidy Joseph F. |
| 主权项 |
1. A liquid composition comprising ibuprofen and diphenhydramine in amounts effective to treat a pain-associated sleep disturbance, wherein the liquid composition consists of:
about 200 to about 400 mg of ibuprofen; about 10 to about 50 mg of diphenhydramine; polyethylene glycol; potassium hydroxide; and water; wherein the liquid composition is formulated inside a soft gelatin capsule, and wherein the polyethylene glycol reduces interaction between the ibuprofen and the diphenhydramine inside the soft gelatin capsule. |
| 地址 |
New York NY US |
