| 发明名称 | High affinity NY-ESO T cell receptors | ||
| 摘要 | The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower. | ||
| 申请公布号 | US9156903(B2) | 申请公布日期 | 2015.10.13 |
| 申请号 | US201213429944 | 申请日期 | 2012.03.26 |
| 申请人 | ADAPTIMMUNE LIMITED | 发明人 | Boulter Jonathan Michael;Jakobsen Bent Karsten;Li Yi;Molloy Peter Eamon;Dunn Steven Mark |
| 分类号 | C07K1/00;C07K14/00;C07K17/00;C07K14/725;C07K14/705;A61K35/12;A61K38/00 | 主分类号 | C07K1/00 |
| 代理机构 | Vedder Price P.C. | 代理人 | Vedder Price P.C. ;Kowalski Thomas J.;Lu Deborah L. |
| 主权项 | 1. A recombinant TCR having the α chain extracellular sequence SEQ ID NO: 1 and the β chain extracellular sequence SEQ ID NO: 2 except that amino acids Q51 and S53 of SEQ ID NO: 1 are replaced by 51M and 53H and amino acid G50 of SEQ ID NO: 2 is replaced by 50S. | ||
| 地址 | Oxford GB | ||