主权项 |
1. A compound according to formula (I):or a pharmaceutically acceptable salt thereof, wherein
Ra and Rb are absent; u is 0; X3 is O; X4 is (CH2)m and X5 is (CH2)n; m and n are each 2; each Z1 group is an optional substituent on any substitutable carbon atom of the ring containing X3, X4, and X5, and is independently alkyl, O(alkyl), oxo, halogen, haloalkyl, or OH; two Z1 groups that are resided on the same carbon atom, together with the carbon atom to which they are attached optionally form a 4-6 membered monocyclic heterocycle ring containing one or two oxygen atoms; p is 0; —X1 is —OH and X2 is hydrogen; G1 is unsubstituted pyrimidinyl or pyridinyl; G2 is G2d wherein
G2d is aryl, optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of Gd, alkyl, alkenyl, alkynyl, halogen, haloalkyl, —CN, —OC(O)Rf, —OC(O)N(Rf)2, —S(O)2Re, —S(O)2N(Rf)2, —C(O)Rf, —C(O)ORf, —C(O)N(Rf)2, —N(Rf)2, —N(Rf)C(O)Rf, —N(Rf)S(O)2Re, —N(Rf)C(O)O(Re), —N(Rf)C(O)N(Rf)2, —(CR1aR1b)q—ORf, —(CR1aR1b)q—OC(O)Rf, —(CR1aR1b)q—OC(O)N(Rf)2, —(CR1aR1b)q—S(O)2Re, —(CR1aR1b)q—S(O)2N(Rf)2, —(CR1aR1b)q—C(O)Rf, —(CR1aR1b)q—C(O)ORf, —(CR1aR1b)q—C(O)N(Rf)2, —(CR1aR1b)q—N(Rf)2, —(CR1aR1b)q—N(Rf)C(O)Rf, —(CR1aR1b)q—N(Rf)S(O)2Re, —(CR1aR1b)q—N(Rf)C(O)O(Re), —(CR1aR1b)q—N(Rf)C(O)N(Rf)2, and —(CR1aR1b)q—CN;R1a and R1b, are the same or different, and at each occurrence are each independently hydrogen, alkyl, or haloalkyl;each occurrence of Rf is independently hydrogen, alkyl, haloalkyl, Gd, or —(CR1aR1b)q-Gd;each occurrence of Re is independently alkyl, haloalkyl, Gd, or —(CR1aR1b)q-Gd;q, at each occurrence, is independently 1, 2, or 3;each occurrence of Gd is independently aryl, heteroaryl, cycloalkyl, heterocycle, or cycloalkenyl; and is each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, haloalkyl, —CN, —OC(O)Rj, —OC(O)N(Rj)2, —S(O)2Rk, —S(O)2N(Rj)2, —C(O)Rj, —C(O)ORj, —C(O)N(Rj)2, —N(Rj)2, —N(Rj)C(O)Rj, —N(Rj)S(O)2Rk, —N(Rj)C(O)O(Rk), —N(Rj)C(O)N(Rj)2, —(CR1aR1b)q—ORj, —(CR1aR1b)q—OC(O)Rj, —(CR1aR1b)q—OC(O)N(Rj)2, —(CR1aR1b)q—S(O)2Rk, —(CR1aR1b)q—S(O)2N(Rj)2, —(CR1aR1b)q—C(O)Rj, —(CR1aR1b)q—C(O)ORj, —(CR1aR1b)q—C(O)N(Rj)2, —(CR1aR1b)q—N(Rj)2, —(CR1aR1b)q—N(Rj)C(O)Rj, —(CR1aR1b)q—N(Rj)S(O)2Rk, —(CR1aR1b)q—N(Rj)C(O)O(Rk), —(CR1aR1b)q—N(Rj)C(O)N(Rj)2, and —(CR1aR1b)q—CN;each occurrence of Rj is independently hydrogen, alkyl, or haloalkyl; andeach occurrence of Rk is independently alkyl or haloalkyl. |