Chromatography apparatus and method

摘要

Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator. The tray can be disposed in a vacuum chamber defined by the lid and the body, and one or more sample containers can be disposed in the tray. When properly positioned in the tray in the vacuum chamber, each container is in fluid communication with a single respective filter assembly disposed in sealing relation in a respective aperture in the lid. A single actuation of a valve causes the lid to seal to the base and drives the simultaneous filtration of a plurality of samples.

主权项

1. A sample preparation device for preparing one or more samples, comprising:
at least one filter assembly having an elongated tip having a longitudinal axis and a fluid outlet, said longitudinal axis being vertically oriented; and a body comprising a base, a sample container tray for holding at least one sample container having a side wall, and a lid, said lid being mounted on said base in sealing relation with said base and defining with said base a vacuum chamber, said lid having one or more apertures in each of which a respective one of said at least one filter assemblies is independently sealingly engaged; wherein said at least one sample container has a longitudinal axis, and wherein said at least one sample container is positioned in said sample container tray such that said longitudinal axis of said elongated tip is not parallel to said longitudinal axis of said sample container, wherein said elongated tip penetrates into said at least one sample container such that fluid flows out said fluid outlet and down said side wall to minimize the trapping of air bubbles.