| 发明名称 |
COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS |
| 摘要 |
<p>The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.</p> |
| 申请公布号 |
PT2268618(E) |
申请公布日期 |
2015.10.12 |
| 申请号 |
PT20090718298T |
申请日期 |
2009.02.27 |
| 申请人 |
NOVARTIS AG |
发明人 |
TOM YAO-HSIANG WU;YONGKAI LI;ALEX CORTEZ;YEFEN ZOU;PRANAB MISHRA;XIAOYUE ZHANG;DAVID SKIBINSKI;MANMOHAN SINGH;NICHOLAS VALIANTE |
| 分类号 |
C07D221/12;A61K31/4375;A61P37/04;C07D471/04;C07D471/12;C07D491/12;C07D495/04 |
主分类号 |
C07D221/12 |
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