HUMAN ANTI-VEGFR-2/KDR ANTIBODIES

摘要

The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

主权项

1. An isolated antibody or fragment thereof that binds to human VEGFR2, comprising a heavy chain variable domain, which comprises and CDR-1H, CDR-2H, and CDR-3H sequence, wherein:
(i) the CDR-1H sequence is GFTFSWYX1MX2 (SEQ ID NO:185), wherein X1 is V or I, X2 is G or L, (ii) the CDR-2H sequence is SIX1X2SGGX3TX4YADSVKG (SEQ ID NO:186), wherein X1 is Y or G, X2 is P or S, X3 is A or F, X4 is N or D, and (iii) the CDR-3H sequence is GNYFDY (SEQ ID NO:3) or GLAAPRS (SEQ ID NO:11).