| 主权项 |
1. A bioconjugate or multimer thereof comprising:
a. a peptide or a polypeptide having the following formula (SEQ ID NO: 1):
X1-X2-X3-R-X5-X6-X7-X8-X9-X10-X11-X12-X13 I wherein: X1 is the N-terminus of the polypeptide and is either absent, Q, A or pE; X2 is R or r; X3 is P or 4-PhP; X5 is L, Cha, D-L, F, Y, Y(Bzl), 3,4-Cl2-F or Nal; X6 is a D-amino acid, S or A; X7 is a D-amino acid, L, H or Aib; and at least one of X6 and X7 is D-amino acid or Aib; X8 is K, k, Q or E; X9 is G or D; X10 is P or pipecolic acid; X11 is D-Nle, Nle, f or D-Nva; X12 is absent, P or a D-amino acid; X13 is the C-terminus and is absent, F or a D-amino acid; and at least one of X11, X12 and X13 is a D-amino acid; wherein: Nle is L-norleucine; D-Nle is D-norleucine; Nal is L-naphthyl)alanine; D-Nva is D-norvaline; Aib is α-aminoisobutyric acid; Cha is (S)-β-cyclohexylalanine; D-Tic is D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; pE is L-pyroglutamic acid; 3,4-Cl2-F is (S)-3,4-dichlorophenylalanine; Y is L-tyrosine; and Y(Bzl) is L-benzyl-tyrosine; or an amide, an ester or a salt of the polypeptide; and
b. a half-life extending moiety; wherein said peptide or polypeptide and half-life extending moiety are covalently linked, optionally via a linker. |
