| 主权项 |
1. A compound of Formula 1: or a pharmaceutically acceptable salt thereof, wherein each n is independently 1 or 2; each R1 and R2 is independently selected from the group consisting of H, optionally substituted C1-C6 alkyl, optionally substituted C3-C7 heterocycloalkyl and optionally substituted C3-C7 cycloalkyl; each R3 is independently selected from the group consisting of H, optionally substituted C1-C6 alkyl, PEG, —C(O)R4, —C(O)OR4, —C(O)NR4, and —S(O)2R4; each R4 when present is independently selected from the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C3-C7 heterocycloalkyl, optionally substituted C3-C7 cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; L is:each X is independently NR5 or O;
each Y is independently selected from the group consisting of a bond, methylene, aryl and heteroaryl; is a single or double bond; each R5 is independently selected from the group consisting of H, optionally substituted C1-C6 alkyl, optionally substituted C3-C7 heterocycloalkyl and optionally substituted C3-C7 cycloalkyl; each k is independently 0, 1, 2, or 3; and m is 1, 2, 3, or 4. |
