DIFFUSIBLE FACTORS AND CANCER CELLS

摘要

The present invention relates to modified cancer cells that are defective in the production of diffusible factors (e.g., growth factors), and to the use of such cells for impairing the growth of a population of human cells, in particular wherein the cells are human cancer cells and the population of cells is a neoplasm, tumour or cancer. The invention preferably comprises the step of modifying tumour cells by deleting or modifying endogenous genes that code for (or affect the production of), diffusible growth factors that promote cell survival and proliferation.

主权项

1. A pharmaceutical composition comprising a population of modified cancer cells, wherein the modified cancer cells are cancer cells which have been modified to reduce or eliminate production of one or more diffusible factors which promote the maintenance or growth of the cancer cells.